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When an STD breaks out, affecting several members of the staff, Webber calls a staff meeting. Later, the chief confides in Derek about his own medical concerns. Izzie and Cristina become stressed when a patient’s wife and daughter can’t decide on his care. Burke treats an old college friend, Bill, but his diagnosis creates questions about his wife. As Meredith and Derek continue to get closer, their relationship crashes down around them when a person from Derek’s past shows up in his life.

The interns treat a patient who, after a series of seizures, thinks he’s gained psychic abilities. Meredith becomes dissatisfied with her relationship with Derek when she realizes that she knows nothing about his personal life. Alex treats a patient whose religion interferes with her recovery; Izzie debates whether or not to reconnect with her mother; and Cristina’s patient disagrees with her medical advice.

Derek and Meredith try to spend a night together at Meredith’s, but their appearance the next morning does more harm than they expected and leads Bailey to tell Meredith to end it. Alex treats a self-mutilation patient, while Izzie’s patient literally won’t let go of his girlfriend. Meanwhile, George is suspicious that an anesthesiologist is drinking on the job and Cristina fills ill with flu-like symptoms.